Michelle Weise Michelle Weise

The Gut-Brain Connection Explained: Why Your Belly Might Be Controlling Your Mood

Have you ever had a “gut feeling” about something? Or noticed that when you're anxious, your stomach feels tight or upset? That’s no coincidence.

Have you ever had a “gut feeling” about something? Or noticed that when you're anxious, your stomach feels tight or upset? That’s no coincidence.

Science is now confirming what many of us have sensed all along — your gut and your brain are in constant communication. This powerful relationship is known as the gut-brain connection, and it's one of the most overlooked keys to better mental and physical health.

Let’s break it down.

Your Gut and Brain Are Always Talking

Your digestive system isn’t just about breaking down food. It's actually home to its own complex neural network, often referred to as the enteric nervous system — or what many experts call your second brain.

This system is deeply wired into your central nervous system. That means what’s happening in your gut can directly impact how you think, feel, and function day to day. This connection is called the gut-brain axis — and it runs both ways.

Translation: What’s going on in your belly affects your brain—and vice versa.

90% of Your Serotonin Is Made in Your Gut

You’ve heard of serotonin, right? It’s the “feel-good” hormone that helps regulate your mood, sleep, and overall sense of well-being.

Here’s the kicker: about 90% of your serotonin is produced in your gut, not your brain.

That means if your gut is inflamed, imbalanced, or overwhelmed by processed foods, stress, or antibiotics, it can literally change how you feel mentally and emotionally. Poor gut health = low serotonin = low mood.

Symptoms of Poor Gut Health on the Mind

When your gut is struggling, your brain often pays the price. Here’s what that can look like:

  • Mood swings that seem to come out of nowhere

  • Anxiety that’s hard to calm

  • Trouble concentrating or brain fog

  • Feeling “off” even when nothing’s wrong externally

These aren’t just mental health issues — they may be gut health symptoms in disguise.

When Your Gut Thrives, So Does Your Mind

The flip side? When your gut is healthy and happy, your brain benefits too.

✔️ You think more clearly
✔️ You feel more emotionally balanced
✔️ You sleep better
✔️ You respond to stress more calmly

It’s all connected.

Taking care of your gut means you're also caring for your mental clarity, emotional health, and even your hormonal balance. That’s the power of the gut-brain axis in action.

Your Second Brain Is in Your Belly

This might blow your mind: your gut has its own nervous system — the enteric nervous system — which can function independently of the brain in your head.

It’s like a mini brain working around the clock to:

  • Regulate digestion

  • Manage immune responses

  • Send signals to your central nervous system

  • Balance hormones and neurotransmitters

So when people say “listen to your gut,” they’re not just being poetic—they’re being scientifically accurate.

What Can You Do to Support a Healthy Gut-Brain Connection?

Here are a few powerful ways to support your gut (and by extension, your brain):

✨ Eat more fermented foods like sauerkraut, kimchi, kefir, and yogurt
✨ Prioritize prebiotic fiber from foods like garlic, onions, bananas, and oats
✨ Limit processed foods and refined sugar
✨ Manage stress with tools like journaling, prayer, deep breathing, and gentle movement
✨ Stay hydrated and get good sleep
✨ Consider a high-quality probiotic or anti-inflammatory meal plan

Final Thoughts: Your Gut Deserves More Credit

Your digestive system is so much more than a food processor—it’s a vital part of your mental health, emotional regulation, and overall wellness.

Want to feel clearer, calmer, and more connected? Start with your gut.

Let’s Get You Started on the Right Track…

💡 Grab the 30-Day Anti-Inflammatory Meal Plan — designed to reset your gut, reduce inflammation, and improve mood, energy, and digestion.
💡 Or check out the Simplify Healthy Eating Membership for done-for-you weekly plans and accountability.

Remember:
A healthy gut = a healthier mind.
And when your gut thrives, so do YOU.

References

  1. Carabotti, M., et al. (2015). The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367209/

  2. Gershon, M. D. (1998). The Second Brain: A Groundbreaking New Understanding of Nervous Disorders of the Stomach and Intestine. HarperCollins.

  3. Clarke, G., et al. (2012). The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Molecular Psychiatry. https://www.nature.com/articles/mp2012105

  4. Sudo, N., et al. (2004). Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. Journal of Physiology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1664920/

  5. Mayer, E. A., et al. (2015). Gut/brain axis and the microbiota. Journal of Clinical Investigation. https://www.jci.org/articles/view/76304

  6. Cryan, J. F., & Dinan, T. G. (2012). Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience. https://www.nature.com/articles/nrn3346

Read More